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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CHEK1
All Species:
21.82
Human Site:
S307
Identified Species:
34.29
UniProt:
O14757
Number Species:
14
Phosphosite Substitution
Charge Score:
0.14
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O14757
NP_001107593.1
476
54420
S307
F
S
P
V
N
S
A
S
S
E
E
N
V
K
Y
Chimpanzee
Pan troglodytes
XP_001145968
476
54387
S307
F
S
P
V
N
S
A
S
S
E
E
N
V
K
Y
Rhesus Macaque
Macaca mulatta
XP_001111357
476
54432
S307
F
S
P
V
N
S
A
S
S
E
E
N
V
K
Y
Dog
Lupus familis
XP_852191
460
52810
S291
F
S
P
V
N
S
A
S
S
E
E
N
V
K
Y
Cat
Felis silvestris
Mouse
Mus musculus
O35280
476
54363
S307
F
S
P
V
N
N
G
S
S
E
E
T
V
K
F
Rat
Rattus norvegicus
Q91ZN7
476
54410
S307
F
S
P
I
N
S
G
S
S
E
E
N
V
K
F
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001513209
476
53924
L307
F
S
P
V
S
S
A
L
S
E
D
K
V
K
Y
Chicken
Gallus gallus
Q8AYC9
476
53830
L307
F
S
P
V
K
S
A
L
G
E
D
K
A
S
Y
Frog
Xenopus laevis
Q6DE87
474
53957
E306
I
S
H
F
S
H
S
E
E
K
T
A
L
S
S
Zebra Danio
Brachydanio rerio
NP_956487
410
46756
P258
A
Q
I
S
S
S
Q
P
E
P
Q
G
L
W
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
O61661
512
57815
N319
Q
S
S
A
H
L
S
N
G
L
D
D
S
I
S
Honey Bee
Apis mellifera
XP_623436
467
53927
P305
C
L
S
Q
P
E
L
P
A
I
E
N
T
N
T
Nematode Worm
Caenorhab. elegans
Q9N3Z3
503
56917
E327
S
A
K
R
R
H
L
E
T
P
N
E
K
S
T
Sea Urchin
Strong. purpuratus
NP_001091925
468
52554
Q307
N
N
K
V
S
S
S
Q
P
T
Y
H
S
N
A
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q84VQ3
439
49610
F268
E
V
L
G
D
A
W
F
K
K
N
Y
K
P
A
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.7
99.3
93.2
N.A.
93.2
94.3
N.A.
89.9
84.4
77.7
56.9
N.A.
46
45.5
32
57.9
Protein Similarity:
100
100
99.7
95.1
N.A.
97
97.2
N.A.
95.3
91.5
86.7
71
N.A.
62.8
63.8
48.7
73.3
P-Site Identity:
100
100
100
100
N.A.
73.3
80
N.A.
73.3
53.3
6.6
6.6
N.A.
6.6
13.3
0
13.3
P-Site Similarity:
100
100
100
100
N.A.
86.6
93.3
N.A.
86.6
60
33.3
26.6
N.A.
40
20
13.3
40
Percent
Protein Identity:
N.A.
N.A.
N.A.
32.9
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
52.1
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
20
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
7
7
0
7
0
7
40
0
7
0
0
7
7
0
14
% A
% Cys:
7
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
7
0
0
0
0
0
20
7
0
0
0
% D
% Glu:
7
0
0
0
0
7
0
14
14
54
47
7
0
0
7
% E
% Phe:
54
0
0
7
0
0
0
7
0
0
0
0
0
0
14
% F
% Gly:
0
0
0
7
0
0
14
0
14
0
0
7
0
0
0
% G
% His:
0
0
7
0
7
14
0
0
0
0
0
7
0
0
0
% H
% Ile:
7
0
7
7
0
0
0
0
0
7
0
0
0
7
0
% I
% Lys:
0
0
14
0
7
0
0
0
7
14
0
14
14
47
0
% K
% Leu:
0
7
7
0
0
7
14
14
0
7
0
0
14
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
7
7
0
0
40
7
0
7
0
0
14
40
0
14
0
% N
% Pro:
0
0
54
0
7
0
0
14
7
14
0
0
0
7
0
% P
% Gln:
7
7
0
7
0
0
7
7
0
0
7
0
0
0
0
% Q
% Arg:
0
0
0
7
7
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
7
67
14
7
27
60
20
40
47
0
0
0
14
20
14
% S
% Thr:
0
0
0
0
0
0
0
0
7
7
7
7
7
0
14
% T
% Val:
0
7
0
54
0
0
0
0
0
0
0
0
47
0
0
% V
% Trp:
0
0
0
0
0
0
7
0
0
0
0
0
0
7
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
7
7
0
0
40
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _